Primary human hepatocytes are protected against prolonged and repeated exposure to ethanol by silibinin-dihemisuccinate.
نویسندگان
چکیده
AIMS AND METHODS We investigated the effect of silibinin-C-2',3'-dihydrogensuccinate (SDH) on primary human hepatocytes when exposed to ethanol for 14 days. At regular intervals, the medium was refreshed and liver enzymes and secreted protein in the medium were determined. RESULTS The ethanol-induced release of lactate dehydrogenase (at 34 mM ethanol) was completely blocked by 20 microM SDH. SDH itself stimulated fibrinogen release and had no toxic effect. CONCLUSIONS We can conclude that SDH has a beneficial effect on human hepatocytes when exposed to ethanol in vitro.
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ورودعنوان ژورنال:
- Alcohol and alcoholism
دوره 38 5 شماره
صفحات -
تاریخ انتشار 2003